Carbon-13 Urea Breath Test For Helicobacter Pylori Infection In Patients With Uninvestigated Ulcer-like Dyspepsia: An Evidence-based Analysis.

- Sep 18, 2016-

BACKGROUND: is a condition defined by or discomfort in the upper gastrointestinal tract that can be caused by . The breath test (641;643;C UBT) is a non-invasive test to detect .: We aimed to determine the diagnostic accuracy and clinical utility of the 641;643;C UBT in adult patients with ulcer-like who have no alarm features.: A literature search was performed using Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid Embase, the Wiley Cochrane Library, and the Centre for Reviews and Dissemination database, for studies published between 2003 and 2012.: We abstracted the sensitivity and specificity, which were calculated against a composite reference standard. Summary estimates were obtained using bivariate random effects regression analysis.: From 19 diagnostic studies, the 641;643;C UBT summary estimates were 98.1% (95% confidence interval [CI], 96.3-99.0) for sensitivity and 95.1% (95% CI, 90.3-97.6) for specificity. In 6 studies that compared the 641;643;C UBT with serology, the 1641;643;C UBT sensitivity was 95.0% (95% CI, 90.1-97.5) and specificity was 91.6 % (95% CI, 81.3-96.4). The sensitivity and specificity for serology were 92.9% (95% CI, 82.6-97.3) and 71.1% (95% CI, 63.8-77.5), respectively. In 1 RCT, symptom resolution, medication use, and physician visits were similar among the 641;643;C UBT, serology, gastroscopy, or empirical treatment arms. However, patients tested with 641;643;C UBT reported higher -specific quality of life scores.: Processing of the 641;643;C UBT results can vary according to many factors. Further, the studies showed significant heterogeneity and used different composite reference standards.: The 641;643;C UBT is an accurate test with high sensitivity and specificity. Compared with serology, it has higher specificity. There is a paucity of data on the 641;643;C UBT beyond test accuracy.: Breath test for detecting in patients with ulcer-like symptoms. is a condition that causes long-term pain or discomfort in the upper abdomen. Symptoms can include heartburn, burping, bloating, nausea, or slow . can be caused by a bacterium that also causes ulcers and . Half of the world's people are believed to be infected with these . A test has been developed to detect the in a breath sample. Our review determined the accuracy of this breath test in adults with ulcer-like symptoms. From 19 studies, the breath test correctly identified 98% of patients with the and 95% of patients without the , as determined by a reference standard. Six studies compared the breath test to a blood test that is currently used. Both the breath and blood tests performed well in correctly identifying patients with the . However, the blood test was incorrectly positive in 20 more patients who did not have the according to the breath test. This means that more patients would have received unnecessary treatment. Thus, the breath test is an accurate test to detect the in adult patients who have ulcer-like symptoms. 

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