The 13C-UBT is the best approach to the diagnosis of H. pylori infection, with high sensitivity and specificity, and excellent performances.
Rapid (‘office’ or ‘near-patient’) serological tests using whole blood could facilitate application of the test-and-treat strategy in general practice. However, these tests have not yet been approved, as their sensitivities and specificities observed to date have generally been disappointing.
In clinical practice when there is an indication for endoscopy, and there is no contraindication for biopsy, the rapid urease test (RUT) is recommended as a first-line diagnostic test. In the case of a positive test, it allows immediate treatment. One biopsy should be taken from the corpus and one from the antrum. RUT is not recommended as a test for H. pylori eradication assessment after treatment.